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3) Limitations in clinical translation and biomarker development: A major translational barrier is the absence of IgA nephropathy-specific, non-invasive ferroptosis biomarkers with clinical utility

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Similarly, a double-blind, cross-over study of a 0.02% capsaicin mouth rinse demonstrated short-horizon analgesic benefit versus placebo, but its utility is constrained by local tolerability (transient burning/stinging, unpleasant taste) and a limited magnitude/duration of effect, with some withdrawals attributable to discomfort during use 34

The hotter the temperature, the shorter the amount of maximum contraction treatment time required [57]

doi:10.1080/00325481.2015.1001712